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Tipo: Artigo de Periódico
Título: Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Autor(es): Cacemiro, Maira da Costa
Cominal, Juçara Gastaldi
Tognon, Raquel
Nunes, Natalia de Souza
Simões, Belinda Pinto
Figueiredo-Pontes, Lorena Lôbo de
Catto, Luiz Fernando Bazzo
Traina, Fabíola
Souto, Elizabeth Xisto
Zambuzi, Fabiana Albani
Frantz, Fabiani Gai
Castro, Fabíola Attié de
Resumo: -
Abstract: Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms.
Palavras-chave: Ph-negative myeloproliferative neoplasms
Inflammation
Plasma cytokines
JAK2 V617F
CNPq: -
Idioma: eng
País: Brasil
Editor: -
Sigla da Instituição: -
Tipo de Acesso: Acesso Aberto
DOI: http://dx.doi.org/10.1016/j.htct.2017.12.003
URI: https://repositorio.ufjf.br/jspui/handle/ufjf/9213
Data do documento: Jun-2018
Aparece nas coleções:Artigos de Periódicos



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