https://repositorio.ufjf.br/jspui/handle/ufjf/9213
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Philadelphia-negative myeloproliferative neoplasms as disorders marked.pdf | 1.74 MB | Adobe PDF | View/Open |
Type: | Artigo de Periódico |
Title: | Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation |
Author: | Cacemiro, Maira da Costa Cominal, Juçara Gastaldi Tognon, Raquel Nunes, Natalia de Souza Simões, Belinda Pinto Figueiredo-Pontes, Lorena Lôbo de Catto, Luiz Fernando Bazzo Traina, Fabíola Souto, Elizabeth Xisto Zambuzi, Fabiana Albani Frantz, Fabiani Gai Castro, Fabíola Attié de |
Resumo: | - |
Abstract: | Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms. |
Keywords: | Ph-negative myeloproliferative neoplasms Inflammation Plasma cytokines JAK2 V617F |
CNPq: | - |
Language: | eng |
Country: | Brasil |
Publisher: | - |
Institution Initials: | - |
Access Type: | Acesso Aberto |
DOI: | http://dx.doi.org/10.1016/j.htct.2017.12.003 |
URI: | https://repositorio.ufjf.br/jspui/handle/ufjf/9213 |
Issue Date: | Jun-2018 |
Appears in Collections: | Artigos de Periódicos |
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