Please use this identifier to cite or link to this item:
https://repositorio.ufjf.br/jspui/handle/ufjf/9185Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives.pdf | 38.77 kB | Adobe PDF |  View/Open |
| Type: | Artigo de Periódico |
| Title: | Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives |
| Author: | Almeida, Mauro Vieira de César, Elói Teixeira Felício, Emanoel de Castro Antunes Fontes, Ana Paula Soares Robert-Gero, Malka |
| Resumo: | O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos. |
| Abstract: | N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic. |
| Keywords: | Platinum(II) complexes N-benzylethylenediamine Anticancer agents Substitution reactions |
| CNPq: | - |
| Language: | eng |
| Country: | Brasil |
| Publisher: | - |
| Institution Initials: | - |
| Access Type: | Acesso Aberto |
| DOI: | http://dx.doi.org/10.1590/S0103-50532000000200009 |
| URI: | https://repositorio.ufjf.br/jspui/handle/ufjf/9185 |
| Issue Date: | Apr-2000 |
| Appears in Collections: | Artigos de Periódicos |
Items in DSpace are protected by Creative Commons licenses, with all rights reserved, unless otherwise indicated.