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dc.creatorAlmeida, Mauro Vieira de-
dc.creatorCésar, Elói Teixeira-
dc.creatorFelício, Emanoel de Castro Antunes-
dc.creatorFontes, Ana Paula Soares-
dc.creatorRobert-Gero, Malka-
dc.date.accessioned2019-02-22T13:35:00Z-
dc.date.available2019-02-21-
dc.date.available2019-02-22T13:35:00Z-
dc.date.issued2000-04-
dc.citation.volume11pt_BR
dc.citation.issue2pt_BR
dc.citation.spage154pt_BR
dc.citation.epage158pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0103-50532000000200009pt_BR
dc.identifier.urihttps://repositorio.ufjf.br/jspui/handle/ufjf/9185-
dc.description.abstractN-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.pt_BR
dc.description.resumoO ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.pt_BR
dc.languageengpt_BR
dc.publisher-pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initials-pt_BR
dc.relation.ispartofJournal of the Brazilian Chemical Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPlatinum(II) complexespt_BR
dc.subjectN-benzylethylenediaminept_BR
dc.subjectAnticancer agentspt_BR
dc.subjectSubstitution reactionspt_BR
dc.subject.cnpq-pt_BR
dc.titleSynthesis of platinum complexes from N-benzyl ethylenediamine derivativespt_BR
dc.typeArtigo de Periódicopt_BR
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