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Métodos de preparação e atividade biológica do ácido quinolínico e derivados.pdf466.35 kBAdobe PDFThumbnail
Type: Artigo de Periódico
Title: Métodos de preparação e atividade biológica do ácido quinolínico e derivados
Other Titles: Methods of preparation and biological activity of quinolinic acid and derivatives
Author: Souza, Marcus Vinícius Nora de
Almeida, Mauro Vieira de
Hyaric, Mireille Le
Cardoso, Sílvia Helena
Amarante, Giovanni Wilson
Resumo: -
Abstract: In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor. As a consequence it possesses neurotoxic activity resulting from overstimulation of the receptor. Quinolinic acid is implicated as an etiological factor in a range of neurodegenerative disease including AIDS related dementia, Huntington´s disease and Lyme disease. In the design of novel therapies to treat these diseases, some molecules have been identified as an important target. In this paper we described different methods to prepare quinolinic acid and derivatives.
Keywords: Quinolinic acid
NMDA receptor
AIDS related dementia
CNPq: -
Language: por
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Oct-2003
Appears in Collections:Artigos de Periódicos

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