|Métodos de preparação e atividade biológica do ácido quinolínico e derivados.pdf
|Artigo de Periódico
|Métodos de preparação e atividade biológica do ácido quinolínico e derivados
|Methods of preparation and biological activity of quinolinic acid and derivatives
|Souza, Marcus Vinícius Nora de
Almeida, Mauro Vieira de
Hyaric, Mireille Le
Cardoso, Sílvia Helena
Amarante, Giovanni Wilson
|In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor. As a consequence it possesses neurotoxic activity resulting from overstimulation of the receptor. Quinolinic acid is implicated as an etiological factor in a range of neurodegenerative disease including AIDS related dementia, Huntington´s disease and Lyme disease. In the design of novel therapies to treat these diseases, some molecules have been identified as an important target. In this paper we described different methods to prepare quinolinic acid and derivatives.
AIDS related dementia
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