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| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives.pdf | 327.97 kB | Adobe PDF |  View/Open |
| Type: | Artigo de Periódico |
| Title: | Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives |
| Author: | Reis, Roberta Cristina Novaes dos Oda, Simone do Carmo Almeida, Mauro Vieira de Lourenço, Maria C. S. Vicente, Felipe R. C. Raposo, Nádia Rezende Barbosa Trevizani, Rafael Santos, Priscila L. C. Hyaric, Mireille Le |
| Resumo: | Diaminas N-monoalquiladas foram sintetizadas e tratadas com D-ribonolactona ou D-gliconolactona. As aldonamidas resultantes foram avaliadas para atividade antimicrobiana contra S. aureus, E. coli, M. tuberculosis and C. albicans. Duas hidrazidas foram também preparadas a partir da ribonoidrazida e suas atividades biológicas comparadas com aquelas de análogos amida. Todos os derivados da ribonolactona mostraram ter atividade antitubercular moderada, alguns foram ativos também contra S. aureus. |
| Abstract: | N-monoalkylated diamines were synthesised and treated with D-ribonolactone or D-gluconolactone. The resulting aldonamides were evaluated for their antimicrobial activity against S. aureus, E. coli, M. tuberculosis and C. albicans. Two hydrazides were also prepared from ribonohydrazide and their biological activity was compared to their amide analogues. All the ribono-derivatives displayed moderated antitubercular activity, and some of them were also active against S. aureus. |
| Keywords: | Antimicrobial M. tuberculosis Amphiphilic Aldonamide |
| CNPq: | - |
| Language: | eng |
| Country: | Brasil |
| Publisher: | - |
| Institution Initials: | - |
| Access Type: | Acesso Aberto |
| DOI: | http://dx.doi.org/10.1590/S0103-50532008000600003 |
| URI: | https://repositorio.ufjf.br/jspui/handle/ufjf/8948 |
| Issue Date: | 2008 |
| Appears in Collections: | Artigos de Periódicos |
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