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Type: Artigo de Periódico
Title: Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
Author: Dias, Alyria Teixeira
Castro, Sandra Bertelli Ribeiro de
Alves, Caio César Souza
Rezende, Alice Belleigoli
Rodrigues, Michele Fernandes
Machado, Rachel Rocha Pinheiro
Fernandes, Adriana
Corrêa, Deborah Negrão
Teixeira, Henrique Couto
Ferreira, Ana Paula
Resumo: -
Abstract: The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Keywords: M. bovis - S
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: 2011
Appears in Collections:Artigos de Periódicos

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