Prevalência da síndrome metabólica e fatores associados em transplantados renais

Abstract

The prevalence of metabolic syndrome (MS) is increasing after renal transplantation and it has been associated to reduction in graft function and increase of cardiovascular risk. So far, there is no available data about MS after renal transplantation in Brazil. The aims of this study are to assess the prevalence of MS and its predisposing risk factors in recipients of renal transplantation. It is a transversal study that included patients with more than six months of renal transplantation. Demographic, clinical and laboratory data were obtained at the patients’s visit to the Clinic. Metabolic syndrome was characterized as proposed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) in its up date in 2005. Among the 87 patients included in the study, 39 (44.8%) had MS. Compared with the patients without MS, those with the syndrome were older, a finding that maintained significant after the multivariated analysis (OR 1.055; CI 95% 1.014 – 1.098, p=0.009), implicating a risk for MS of 5.5% for each year of life. Treatment with beta blockers OR 3.523; CI 95% 1.351 - 9.187, p=0.01) and the presence of post-transplant diabetes mellitus (p<0.001) was also associated with MS. In conclusion: The prevalence of MS in 44.8% of the patients studied is higher than that found in the general population and was associated with older age, post-transplant diabetes mellitus and treatment with beta blockers.