Sobrevida livre de doença e fatores associados em pacientes com câncer de mama não metastático

Abstract

Breast cancer is a public health problem, being the second most common in the world and the highest incidence in the female population, in addition to being a major cause of death from cancer in this population overall. The aim of this study was to analyze the disease-free survival (DFS) at five years and prognostic factors in women with non metastatic invasive breast cancer diagnosed between 2003 and 2005 and treated at a referencial center of cancer care on a medium sized town of Southeast. Patients were identified using the medical records and data from the cancer registries of the institution. The follow up of the cases were performed using hospital records, supplemented by searching the database of the Mortality Information System (SIM) and telephone contact. The variables analyzed were: sociodemographic (age at diagnosis, race, education level, family history of breast cancer and presence of diagnostic mammography), related to tumor characteristics (size, lymph node involvement, stage, neurovascular invasion, tumor grade, immunohistochemical profile), characteristics related to treatment (type of surgery, use of chemotherapy, radiotherapy and hormone therapy, completion of chemotherapy, time between surgery and adjunctive therapy). Survival functions were calculated using the Kaplan-Meier model while the Cox proportional hazards method was used to evaluate prognostic factors. The study showed a disease-free survival at 60 months 72% (95% CI 67.6 to 75.9). The main variables associated with SLD, independently, were lymph node involvement, use of hormone therapy and degree of schooling. This study showed the importance of early diagnosis in DFS. This research is relevant due the lack of studies regarding the DFS at the Brazilian population.