“Síntese e caracterização de complexos de paládio(II), platina(II), zinco(II) e cobre(II) com ligantes do grupo das fluorquinolonas”

Abstract

Fluoroquinolones are part of an important family of synthetic anti-microbial agents being clinically used over the past thirty years. In addition, some fluoroquinolones have been used in the development of anticancer drugs, and others have demonstrated anti-HIV activity. Aiming to obtain novel platinum(II) and other metal ion complexes that exhibit biological activity, we have synthesized complexes using fluoroquinolones as ligands. The interactions between fluorquinolones and metal ions have been investigated due to the interest in their biological and chemical properties. Investigations have conducted to identify the groups directly bound to the metal and in the structure of the coordination compounds formed. In this context, this work describes the synthesis of palladium(II), platinum(II), zinc(II), and cupper(II) complexes with fluorquinolones. The compounds were characterized using IR spectroscopy, 1H NMR, 13C NMR, 195Pt NMR, mass spectroscopy, x-ray crystallography, conductimetric, thermogravimetric and elemental analysis.