Uso clínico de canabidiol em patologias neurológicas: uma revisão narrativa

Abstract

In recent decades, there has been increasing interest in the therapeutic potential of Cannabis derivatives for neurological disorders, with a strong stimulus for research in several areas, such as refractory epilepsy and symptoms of multiple sclerosis (MS). The present study aims to perform a narrative review regarding the therapeutic use of cannabidiol (CBD) derivatives for alternative use in the treatment of neurological conditions, especially in epilepsy and MS. As a result, 46 articles that met the inclusion criteria were selected. The results of this study showed that most patients with refractory epilepsy who used CBD as monotherapy or complementary treatment showed total or partial improvement. It was also possible to observe through this study the evidence of the use of CBD to provide a clinically relevant improvement of resistant spasticity in MS compared to first-line antispasticity drugs alone. However, the use of CBD is limited for certain groups, including lactating women, the elderly, and pregnant women, due to the lack of safety and efficacy data for them. Therefore, this study represents a contribution to a better understanding of the potential therapeutic use of cannabidiol in the treatment of epilepsy and MS.