Avaliação da função endotelial em pacientes com periodontite crônica e doença renal crônica

Abstract

Chronic kidney disease is considered a public health problem worldwide, mainly due to the high morbidity and mortality. The progressive and irreversible loss of renal function provides several complications. Evaluation of risk factors is key to reducing risks of death in patients with chronic renal failure. Cardiovascular disease is the leading cause of death by disease after infection. In order to assess endothelial function were included 35 patients divided into three groups (15 with chronic kidney disease and chronic periodontitis, 10 with chronic periodontitis with no systemic disease and 10 healthy controls). Chronic kidney disease was defined as suggested by the Practice Guideline for the National Kidney Foundation. Chronic periodontitis was defined by probing depth and clinical attachment level, according to the American Academy of Periodontology. Levels of C-reactive protein were measured by ELISA technique. Endothelial function was presented reduced in patients with chronic kidney disease and those with chronic periodontitis and chronic periodontitis with no systemic disease compared to healthy control group. Levels of C-reactive protein had to be high in groups with chronic kidney disease with chronic periodontitis and chronic periodontitis with no systemic diseases in the control group. Patients with clinical attachment level ≥ 6 mm were more in the group with chronic renal failure patients with chronic periodontitis was statistically significant when compared to the other two groups. Chronic periodontitis induces a systemic inflammatory response and patients with chronic kidney disease presented with the utmost gravity.