Efeito da suplementação de vitamina d na composição corporal, força muscular e capacidade ao exercício de pacientes com doença de Crohn em remissão e hipovitaminose D: estudo piloto de um ensaio clínico randomizado placebo- controlado, duplo-cego

Abstract

Background: Low total 25-hydroxyvitamin D (25(OH)D) serum levels have been identified around 70% of Crohn disease (CD) patients, as well have been associated with muscle dysfunction. Objective: This pilot study aimed to determine the effect of vitamin D supplementation on body composition, muscle strength, and exercise capacity in patients with CD in remission and hypovitaminosis D. Methods : This was a 6-month prospective, randomized, double-blind, parallel-group clinical pilot trial that enrolled 23 CD patients in remission with 25(OH)D serum level <30 ng/mL. The intervention group received week supplementation (25(OH)D 50000 IU) while the control group received placebo inert substance with the same posology during 6 months. 25(OH)D serum levels, body composition, anthropometric parameters, muscle strength, and exercise capacity were determined at the baseline and at the end of the study. Results: Mean age was 39 ± 10 years. 25(OH)D serum levels increased from 19.7 ± 5.5 nmol/L to 32.8 ± 6.0 nmol/L (p<0.001) in the intervention group, while remaining low in the placebo group (baseline and final levels at 23.4 ± 3.2 nmol/L and 22.8 ± 2.0 nmol/L respectively). Body composition (fat mass, muscle mass), anthropometric parameters (abdominal and waist circumference), muscle strength and exercise capacity did not change in any of the groups. Conclusion: Vitamin D supplementation, at the doses provided in our study, despite to correcting low serum levels, does not have effects in body composition, muscle strength and exercise capacity in CD patients in remission. Since these were preliminary results, therefore, to the need for further studies.