Síntese, caracterização e avaliação antiparasitária e antiviral de derivados de aminoquinolinas, 1,2,3-triazóis e seus sais

Abstract

In the present work, 50 compounds have been synthesised, including 24 novel molecules, with the goal to produce an enhanced biological activity, compared to the most promising compounds published by our research group. For this purpose, the synthetic approach consisted in the insertion of functional groups, organic salt formation or molecular hybridisation. Among the synthesised compounds, are included quinolinic derivatives inserted of nitro or amino groups and their salts, 1,2,3-triazoles and their salts and hybrid molecules combining the quinolinic and 1,2,3-triazolic nuclei. The compounds have been correctly characterised and the results from the biological assay against leishmaniasis, malaria and SARS-CoV-2 were presented and showed good potential, in some cases demonstrating a superior inhibiting performance in relation to the preceding compounds and reference drugs, with low cytotoxicity to mammalian cells.