Uso da proteína morfogenética óssea em defeitos bucomaxilofaciais: aplicabilidade, eficácia e segurança

Abstract

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-b superfamily and are involved in the differentiation of pluripotent mesenchymal cells and the formation of new bone by osteoblastic induction. The use of BMP-2 has been extensively studied at different sites in the oral and maxillofacial regions. This study aimed to conduct a literature review in order to elucidate the use of BMPs for the treatment of oral and maxillofacial bone defects. The morphogenetic bone protein has been shown to be closely linked to the osteoblast differentiation process and consequently to bone regeneration. Its effectiveness in the repair of bone defects is linked to the type of carrier, dosage and growth factors that can be associated, in addition to the good practice of bone tissue regeneration, offering space and blood supply. It may be related to inflammatory responses, cancer and ectopic bone formation, its use in the region was maxillofacial only associated with exacerbated edema in the articles consulted. Therefore, the application of the protein is an effective option to achieve bone regeneration in the maxillofacial region.