Please use this identifier to cite or link to this item:
Type: Artigo de Periódico
Title: Synergism in the antibacterial action of ternary mixtures involving silver nanoparticles, chitosan and antibiotics
Author: Brasil, Marcelo S. L.
Filgueiras, Aline L.
Campos, Marina B.
Neves, Mariana S. L.
Eugênio, Mateus
Sena, Lídia A.
Sant'Anna, Celso B.
Silva, Vânia L. da
Diniz, Cláudio Galuppo
Sant'Ana, Antonio C.
Resumo: -
Abstract: The investigations of the antibacterial actions, observed in ternary associations involving silver nanoparticles (AgNPs), chitosan and the antibiotics azithromycin (AZ), levofloxacin (LE) or tetracycline (TE), against Gram-negative and Gram-positive bacterial strains, were performed by in vitro antimicrobial susceptibility testing and checkerboard assays. The pH impact in the culture medium was carefully discarded, but preserving the best conditions for solubilizing chitosan. The synergistic antibacterial effects were observed in the most combinations of AgNPs, chitosan and antibiotic, leading to a reduction from 37 to 97% in the minimum inhibitory concentration of the drugs. The mechanisms for the enhanced antimicrobial effects were proposed based on the investigations of the adsorptions of the drugs on the silver surfaces through surface-enhanced Raman scattering (SERS) spectroscopy.
Keywords: Surface chemistry
Ag+ ion
LSPR spectroscopy
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Oct-2018
Appears in Collections:Artigos de Periódicos

Items in DSpace are protected by Creative Commons licenses, with all rights reserved, unless otherwise indicated.