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Type: Artigo de Periódico
Title: Reações de Ortometalacão em Piridinas
Author: Souza, Marcus .V. N. de
Almeida, Mauro Vieira de
Resumo: -
Abstract: In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products.
Keywords: Ortho-metalation
Directed metallation group
Heteroaromatic compounds
CNPq: -
Language: por
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Feb-2002
Appears in Collections:Artigos de Periódicos

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