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Type: Artigo de Periódico
Title: Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinocarbinolaminas antimaláricas: proposta de um farmacóforo
Other Titles: Molecular modeling study of complexes between ferriprotoporphyrin IX and antimalarial 4-quinolinecarbinolamines: a proposal of pharmacophore
Author: Silva, Thais Horta Álvares da
Oliveira, Marcelo Tavares de
Santos, Hélio Ferreira dos
Oliveira, Alaíde Braga de
Almeida, Wagner Batista de
Resumo: -
Abstract: Quinine and quinidine are well-known 4-quinolinecarbinolamines that exhibit antimalarial activity, but, in contrast, their epimers 9-epiquinine and 9-epiquinidine are almost inactive. Literature data are conflicting in describing the 4-quinolinecarbinolamine interaction mode with the molecular target, the ferriprotoporphyrin IX [Fe(III)PPIX]. In the present paper, a pharmacophore is proposed based on the binding of the non-aromatic nitrogen to the iron atom. The 4-quinolinecarbinolamine antimalarials were superimposed on the pharmacophore under consideration and complexes with Fe(III)PPIX were constructed. Conformational analyses of the complexes were performed applying the MM+ molecular mechanics method. The analysis of the complexes showed that the proposed ligand mode is possible although it does not explain the activity differences between epimers. A discussion of the structural aspects is also provided.
Keywords: Antimalarial
Quinine
Pharmacophore
CNPq: -
Language: por
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
DOI: http://dx.doi.org/10.1590/S0100-40422005000200015
URI: https://repositorio.ufjf.br/jspui/handle/ufjf/9056
Issue Date: Apr-2005
Appears in Collections:Artigos de Periódicos



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