Avaliação nutricional e atividade inflamatória sistêmica de pacientes com câncer colorretal submetidos à suplementação com simbiótico

Abstract

BACKGROUND: Nutritional depletion in patients with advanced colorectal cancer, even with adequate weight, may be associated with co-morbidity factors such as: reduction of immunity, increased rate of infections, impaired cicatrization and muscle weakness. Immunomodulating diets have recently been used as a nutritional approach to cancer patients. Prebiotics, probiotics and symbiotics (a mixture of the first two) have been studied. AIM: To assess the Nutritional Status and Systemic Inflammatory Activity of colorectal patients on symbiotic supplementation. It was a progressive longitudinal study in colorectal cancer patients. METHODS: All patients underwent assessment of nutritional status and subsequent serological analysis, daily use of the symbiotic supplement, anthropometric and biochemical assessment every three months Besides anthropometric data, the following blood components were measured: C-reactive protein (CRP), carcino-embryonic antigen (CEA) and albumin. RESULTS: The mean CRP level at baseline, before symbiotic administration, was 11 mg/dL, with a reduction to below 6 mg/dL at the end of the study. CONCLUSION: There was a beneficial effect of symbiotic supplementation, because although albumin and CEA levels were stable during the study, there was a CRP reduction in meantime.