A ativação endotelial nos pacientes submetidos à quimioterapia em alta dose para transplante de medula óssea

Abstract

Introduction: the objective of this Study is to evaluate the relationship between inflammatory markers and other factors that influence platelet consumption and platelet transfusion increment, as well as the presence of thromboembolic events in patients submitted to high-dose chemotherapy regimens for Bone Marrow Transplantation. Method: prospective analysis of patients, including 25 patients who underwent autologous and allogenic Bone Marrow Transplantation. The patients were evaluated in relation to previous radiotherapy, CD34+ cell count, period of neutropenia, body mass index, ferritin, C-reactive protein, relating these factors to the number of platelet transfusions, platelet refractoriness and vascular events such as sinusoidal obstruction syndrome and Engraftment Syndrome. Results: only body mass index > 25 Kg/m2 of the studied variables presented a statistically significant value (p = 0.003) in relation to the lower rates of platelet transfusion. For platelet refractoriness and/or vascular events none of the variables was statistically significant. Conclusion: the conditions found in the three cases of platelet refractoriness and in the two cases of vascular events have characteristics similar to those described in the literature. We agree with preexisting data reported in the literature, where patients with high BMI have lower need of platelets transfusion.