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Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina.pdf166.09 kBAdobe PDFThumbnail
Type: Artigo de Periódico
Title: Síntese e avaliação da atividade antimalárica de compostos derivados da curcumina
Other Titles: Synthesis and evaluation of antimalarial activity of curcumin derivatives
Author: Gomes, Patrícia Ramos
Miguel, Fábio Balbino
Oliveira, Michael Éder de
Ferreira, Vanessa Viana
Guimarães, Daniel Silqueira Martins
Lima, Aline Brito de
Barbosa, Camila de Souza
Oliveira, Mariana Amorim de
Almeida, Mauro Vieira de
Viana, Gustavo Henrique Ribeiro
Couri, Mara Rubia Costa
Varotti, Fernando de Pilla
Resumo: -
Abstract: One of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC50 values ranging from 1.7 to 15.2 µg mL-1), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds.
Keywords: Curcumin derivatives
Antimalarial chemotherapy
Plasmodium falciparum
CNPq: -
Language: por
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: May-2014
Appears in Collections:Artigos de Periódicos

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