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Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic .pdf921.87 kBAdobe PDFThumbnail
Type: Artigo de Periódico
Title: Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential
Author: Chaves, Alexandre Silva
Rodrigues, Michele Fernandes
Mattos, Ana Márcia Menezes
Teixeira, Henrique Couto
Resumo: -
Abstract: Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important systems of host-pathogen interaction. This genetic mechanism allows the mycobacteria to persist during long time periods, establishing the so-called latent infection. Even in the presence of a competent immune response, the host cannot eliminate the pathogen, only managing to keep it surrounded by an unfavorable microenvironment for its growth. However, conditions such as immunosuppression may reestablish optimal conditions for bacterial growth, culminating in the onset of active disease. The interactions between the pathogen and its host are still not completely elucidated. Nonetheless, many studies are being carried out in order to clarify this complex relationship, thus creating new possibilities for patient approach and laboratory screening.
Keywords: Tuberculosis
DosR antigens
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Nov-2015
Appears in Collections:Artigos de Periódicos

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