Please use this identifier to cite or link to this item:
Files in This Item:
File Description SizeFormat 
Lack of association between genetic polymorphism.pdf375.58 kBAdobe PDFThumbnail
Type: Artigo de Periódico
Title: Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity
Author: Pereira, Patrícia de Araújo
Soares Junior, António Marcos Alvim
Sandrim, Valéria Cristina
Lanna, Carla Márcia Moreira
Costa, Débora Cristine Souza
Belo, Vanessa de Almeida
Paula, Jonas Jardim de
Santos, José Eduardo Tanus
Silva, Marco Aurélio Romano
Miranda, Débora Marques de
Resumo: -
Abstract: Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance.Methods:This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.
Keywords: Single-nucleotide polymorphisms
Childhood obesity
Fat mass and obesity associated
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Sep-2016
Appears in Collections:Artigos de Periódicos

Items in DSpace are protected by Creative Commons licenses, with all rights reserved, unless otherwise indicated.