Síntese, caracterização e avaliação biológica de derivados pirazolínicos obtidos a partir de chalconas e curcuminas

Abstract

This work describes the synthesis of pyrazolines, hydrazones, chalcones, enones and curcumines, resulting in sixty-nine new compounds. The interest in obtaining chalcones, enones, curcumines, and their synthetic analogues is due to numerous pharmacological properties described for these classes of compounds. Thirty-seven chalcone, nine curcumin analogues and thirteen enones were obtained via a Claisen-Schmidt reaction. Long-chain aldehydes and ketones were obtained via Williamson ether synthesis. Sixteen chalcone derivatives were evaluated in vitro for their schistosomicidal activity. The results showed that some compounds were able to cause death and reduction in motor activity in 100% of the parasites. The synthesized pyrazolines were evaluated for their antitubercular, antibacterial, anti-Trypanosoma cruzi, anticandidal, antitumor activities. A vibrational study of tautomerism from pyrazoline derivatives has been performed by Raman spectroscopy in solid form and CHCl3 solution. This study suggests the existence of tautomers, in the solid state or in solution.