Modelo matemático-computacional reduzido para potencial de ação, dinâmica de cálcio e tensão ativa de cardiomiócitos

Abstract

The simulation of the electromechanical activity of the heart is a relevant tool for the interpretation and study of physiological measures and several cardiac phenomena. However, computational models for this purpose can be computationally expensive. In view of the above, this work presents minimal simplified models, at the cellular level, capable of qualitatively reproducing cardiac electromechanical activity considering electrical, calcium and mechanical relationships. For the development of the models, coupling was performed between the minimal model of Bueno-Orovio, the electrical part, and simplified models for equations of calcium and active tension. To obtain the model parameters a genetic algorithm was used. The proposed models with adjusted parameters allowed the reproduction of the action potential, calcium and active force of the heart with the advantage of being supported by only six ordinary differentials.