Osteonecrose medicamentosa em mandíbula: relato de caso

Abstract

Drug-related osteonecrosis (ORM) is a serious and debilitating complication, the incidence of which has increased in recent decades. It is defined as exposed bone in the maxillofacial region that does not heal within eight weeks of identification by a healthcare professional; with exposure to an antiresorptive or antiangiogenic agent; and no history of radiotherapy to the craniofacial region. This condition is often accompanied by pain, infection, and jaw dysfunction, and it can present from mild symptoms to severe complications. Among the most commonly associated medications are bisphosphonates. This study aims to describe a clinical case report of a 60-year-old melanoderma, diabetic and hypertensive female patient with osteonecrosis in the mandible, associated with the use of bisphosphonate. The clinical characteristics, related risk factors, diagnosis and therapeutic management of the case were discussed. It is a condition associated with several risk factors whose diagnosis and treatment are challenging. The diagnosis requires a complete and detailed evaluation, considering clinical and radiological aspects, medication history, and the patient's health conditions. Treatment options can range from conservative approaches to more invasive methods, depending on the severity of the disease. However, a multidisciplinary and therapeutic approach is crucial for better prognosis and to ensure effective and integrated management of the disease.