Cisplatina: um exemplo de metalofármaco inorgânico

Abstract

The use of metals in treatment has always been present in ancient civilizations, but with the development of medical sciences, understanding the toxicity associated with them has impacted the reduction in the development of metallic formulations. Nevertheless, the therapeutic effect of metallodrugs is undeniable, with cisplatin being one of the main representatives of this group, if not the most important. The discovery of cisplatin's antitumor activity is a milestone in Medicinal Inorganic Chemistry, and its use combined with the improvement in prognosis for solid tumor treatments, has significantly increased survival rates and regression rates for these types of cancers. Research on this metallodrug is extensive, with numerous review articles and clinical trials available in the literature. Therefore, the motivation for this work/article is not to provide a systematic review of cisplatin, but to offer an approach tailored to students in the early stages of their pharmacy undergraduate studies.. For this scope, it is suggested to prepare an article for publication in the journal Química Nova na Escola, to be included in the “Atualidades em Química” section, given that the training of pharmaceutical professionals still has its foundations rooted in this science. In addition to providing historical accounts, the approach focuses in a very simple way on the pharmacological aspects of cisplatin activity, explaining concepts of all parts of the pharmacokinetics and pharmacodynamics of this metallic complex.