Quantificação da influência da velocidade do sangue no dano tecidual em tratamentos de câncer por hipertermia

Abstract

In 2020, cancer was responsible for approximately 10 million deaths worldwide. There are several treatments to fight cancer, such as chemotherapy, radiotherapy, immunotherapy, bone cell transplantation, among others. Hyperthermia is a new treatment that is under clinical study. The idea of this treatment is to increase the temperature of the target tumor to a temperature capable of leading the cells to necrosis. Thus, mathematical-computational models are widely used to simulate the dynamics of this type of treatment. Models of bioheat transfer in porous media have been used to simulate this treatment, but there is no consensus on the values used in some parameters, such as blood velocity, which can impact the results. In this work, an analysis of the influence of blood velocity was performed through the quantification of uncertainties in the parameter that defines the blood velocity in the mathematical model. In addition, we use an approach that takes advantage of data parallelism to accelerate the achievement of model results, thus, it was possible to compare the performance of the parallel algorithm in relation to its serial version. The results suggest how much the blood velocity parameter affects the efficiency of this type of treatment, being important to allow adjustments in the treatment and to obtain success in this type of treatment.