Síntese e avaliação da atividade antifúngica de complexos metálicos contendo 2-piridinoaldazina como ligante

Abstract

Like organic molecules, metals are fundamental for the development of life. They are usually found attached to electron-rich organic molecules forming metal complexes. However, only in the last century did the medicinal properties of these elements begin to be rationally investigated. Among the molecules that have shown potential for the development of new products, azines, which are compounds characterized by the presence of the skeleton R 1 R 2 C=N-N=CR 3 R 4 , have demonstrated their value for acting as precursors in the synthesis of some heterocycles and their ability to act as metal ions. In addition, there are reports in the literature of several azines and their complexes that can manifest biological activities, such as antimicrobial, cytotoxic, enzyme-mimicking, among others. Aiming to expand the knowledge about the ability of azines to coordinate and their biological use, 2- pyridinoaldazine and its Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized. The compounds were characterized by measuring the conductivity of the solution, electronic spectroscopy in the infrared region, vibrational spectroscopy in the visible ultraviolet region, thermal analysis and hydrogen nuclear magnetic resonance spectrometry. The results indicated that, except for Fe(II) complex (metal:ligand stoichiometry = 2:1), all the others coordinated following a 1:1 stoichiometry (metal:ligand). After characterization, a study of the antifungal activity of these compounds was initiated. The fungus used was Saccharomyces cerevisiae ATCC 9763. Preliminary results showed that only the Fe(II) complex demonstrated activity among the studied compounds. These results demonstrate the importance of further studies to understand the pharmacological potential of these compounds.