Mikania glomerata Sprengel (Guaco): obtenção de extrato seco e determinação do nível de cumarina por espectrofotometria

Abstract

For the development of herbal medicine in the solid form of the medicinal plant Mikania glomerata Sprengel, popularly known as "guaco", following the RDC March 14, 2010, several steps need to be developed under the technological and pharmacotecnical point of view. To study the processes of obtaining dry extract guaco, for the production of hard gelatin capsules, containing coumarin consistent therapeutic concentration provides the means to meet the cast and Drug Reference Inputs Complementary to the Pharmaceutical Care in Primary Health Care (2.982/GM/MS Ordinance, 2009), necessary to complement the popular health. We started from hydroalcoholic guaco produced from the dried leaves, grown in the Garden of Medicinal FF / UFJF. The study was carried evaporation techniques to extract fluid guaco in an oven in the hot water bath and rotaevaporator and concentration of the extract by lyophilization and spray-dryer atomization. The techniques of evaporation of fluid extract of guaco methods used by kiln drying, in a hot water bath and rotaevaporator were not appropriate, as the final product resulting soft guaco extract. The technological methods used concentration by applying the processes of freeze-drying and spray-dryer were satisfactory. The final products presented with appearance of a dry powder, homogeneous, light brown, considered good looking pharmacotechnical for the production of hard gelatine capsules. Reported a greater mass of dry extract guaco by freeze-drying process in relation to the spray-dryer. Also the concentration of coumarin observed in assay, were superior in the same technique as compared to spray-dryer. The advantage observed in the atomization process by spray-dryer was over time, lower, compared to freeze-drying. This study was possible to establish a technical / scientific to obtain Dry Guaco Extract necessary to the manufacture of hard capsules containing Mikania glomerata Sprengel, following the quality criteria in the DRC 14 March 31, 2010 and given the National Program for Medicinal Plants and Herbal Medicines (PNPMF) approved by the federal government through the Presidential Decree. 5813 to June 22, 2006.