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Type: Trabalho de Conclusão de Curso
Title: New promising leads from natural sources against Cryptococcus sp. an Candida sp.: an 8 years review
Author: Sathler, Ana de Araújo
First Advisor: Lang, Karen Luise
Referee Member: Ferreira, Gabriella Freitas
Referee Member: Medeiros, Vanessa Gonçalves
Resumo: ---
Abstract: Systemic fungal infections caused by fungal species of the genus Candida sp. and Cryptococcus sp. have important epidemiological significance, because they affect immunocompromised patients and present high mortality rates. The available drugs used for the treatment of the diseases caused by these fungi species are restricted of three classes of antifungals. Besides the limited number of therapeutic alternatives, these drugs are associated with several factors that limiting its use, such as the incidence of serious adverse effects, drug interactions, development of resistance and high cost, justifying the search for new chemical entities. Natural products are historically relevant sources of compounds for the development of new drugs, and studies with these organisms has resulted in the discovery of new molecules with anti-cryptococcus and anti-candida activity. In this review, 125 molecules with minimal inhibitory concentration (MICs) in the range of 0.63 to 50 μg mL -1 were compiled. 88% of these molecules were active against the different species of Candida sp. and 35.2% were active against fungi of the genus Cryptococcus sp.. 77.6% were molecules isolated from plants, 8% isolated from microorganisms and 13.6% isolated from algae and marine sponges.
Keywords: Cryptococcus
natural products
Language: eng
Country: Brasil
Publisher: Universidade Federal de Juiz de Fora - Campus Avançado de Governador Valadares
Institution Initials: UFJF/GV
Department: ICV - Instituto de Ciências da Vida
Access Type: Acesso Aberto
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Issue Date: 6-Dec-2018
Appears in Collections:Farmácia - Campus GV

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