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Type: Artigo de Periódico
Title: IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase
Author: Gusmão, Michélia Antônia do Nascimento
Emídio, Nayara Braga
Marconato, Danielle Gomes
Farani, Priscila Silva Grijó
Maniezzi, Luiz Felipe
Coelho, Paulo Marcos Zech
Oliveira, Rodrigo Correa
Vasconcelos, Eveline Gomes
Faria-Pinto, Priscila de
Resumo: -
Abstract: Introduction: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins. Methods: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity. Results: Most of the schistosomiasis patient’s (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. C57BL/6 mice immunized with potato apyrase showed increased IgE antibody production. Conclusions: Potato apyrase and SmATPDases have IgE-binding epitopes.
Keywords: ATP diphosphohydrolase
Potato apyrase
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: 28-Mar-2019
Appears in Collections:Artigos de Periódicos

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