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dc.creatorChebli, Júlio Maria Fonseca-
dc.creatorGaburri, Pedro Duarte-
dc.creatorSouza, Aécio Flávio Meirelles de-
dc.creatorDias, Kátia Valéria Bastos-
dc.creatorCimino, Karla Oliveira-
dc.creatorCarvalho-Filho, Roberto José de-
dc.creatorLucca, Fernando de Azevedo-
dc.description.abstractThe authors describe the case of a young Brazilian woman who was treated of ileocolonic Crohn's disease sparing rectum, as confirmed by colonoscopy and histopathological examination. After a 4-year course of sulfasalazine treatment, she presented with skin facial lesions in vespertilio, fever, arthralgias and high titers of anti-ANA and LE cells. A sulfasalazine-induced lupus syndrome was diagnosed, because after sulfasalazine withdrawal and a short course of prednisone, the clinical symptoms disappeared and the laboratory tests returned to normal. Mesalazine 3 g/day was started and the patient remained well for the next 3 years, when she was again admitted with fever, weakness, arthralgias, diplopy, strabismus and hypoaesthesia in both hands and feet, microhematuria, haematic casts, hypocomplementemia and high titers of autoimmune antibodies. A diagnosis of associated systemic lupus erythematosus was made. Although a pulsotherapy with methylprednisolone was started, no improvement was noticed. A cyclophosphamide trial was tried and again no positive results occurred. The patient evolved to severe clinical manifestations of general vasculitis affecting the central and peripheral nervous system and lungs, having a fatal evolution after 2 weeks. Although uncommon, the association of both disease may occur, and the authors call attention to this possibility, making a brief review of literature.pt_BR
dc.relation.ispartofArquivos de Gastroenterologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCrohn diseasept_BR
dc.subjectLupus erythematosuspt_BR
dc.titleFatal evolution of systemic Lupus erythematosus associated with Crohn's diseasept_BR
dc.typeArtigo de Periódicopt_BR
Appears in Collections:Artigos de Periódicos

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