Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Abstract

The present work investigated the analgesic and anti-inflammatory activities of the methanol extract of the rhizomes of Echinodorus grandiflorus. For this purpose, acetic acid writhing, paw licking induced by formalin, carrageenan-induced rat paw edema and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg inhibited the contortions 34.30%, 35.84% and 36.07%, respectively. The lick of the paw 1st phase was reduced at the doses of 200 and 400 mg/kg, while the 2nd phase had reduction at 400 mg/kg. All doses inhibited the paw edema, while the volume of the exsudate was reduced 24.61% in the dose of 400 mg/kg. The doses of 200 and 400 mg/kg decreased the leukocytes migration. The results indicate that the methanol extract of E. grandiflorus can constitute target potential for use in therapies of the pain and inflammation.