Obtenção de dispersões sólidas contendo quercetina: análises por técnicas espectroscópicas de difração de raios x, infravermelho, raman e ressonância magnética nuclear de sólidos

Abstract

Quercetin (QUER) is a polyphenolic flavonoid, which are credited several pharmacological actions, highlighting the antioxidant, hepatoprotective and anti-inflammatory effects. However, the low solubility in water is a limiting factor for the development of pharmaceutical preparation, particularly those of oral use. Thus, to improve their biopharmaceuticals limitations, the aim of this study was to incorporate quercetin in solid dispersions systems. Solid dispersions (DS) were prepared by the solvent evaporation method using the carriers, hydroxypropylmethylcellulose (HPMC), polyethylene glycol 4000 and Pluronic F127 in proportions of 1:1, 1:2 and 1:4 using two conditions for solubilization (water:alcohol and acetone:alcohol 1:4). The DS were analyzed by the X-ray Infrared, Raman, Nuclear Magnetic Resonance spectroscopy techniques. Considering the employed techniques, the dispersion containing QUER:HPMC (1: 4), from acetone/ethanol, yielded an amorphous state that was observed by the changes in the intensities of the spectra and diffractograms. Therefore, the dispersion containing QUER:HPMC (1:4) may be an important preparation for oral solid formulations, allowing a better solubility of quercetin in biological media and hence an increase of their bioavailability.