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Type: Artigo de Periódico
Title: Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Author: Cacemiro, Maira da Costa
Cominal, Juçara Gastaldi
Ribeiro, Raquel Tognon
Nunes, Natalia de Souza
Simões, Belinda Pinto
Pontes, Lorena Lôbo de Figueiredo
Catto, Luiz Fernando Bazzo
Traina, Fabíola
Souto, Elizabeth Xisto
Zambuzi, Fabiana Albani
Frantz, Fabiani Gai
Castro, Fabíola Attié de
Resumo: -
Abstract: Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms.
Keywords: Ph-negative myeloproliferative neoplasms
Plasma cytokines
JAK2 V617F
CNPq: -
Language: eng
Country: Brasil
Publisher: -
Institution Initials: -
Access Type: Acesso Aberto
Issue Date: Apr-2018
Appears in Collections:Artigos de Periódicos

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