Modelos simplificados para acoplamento eletromecânico do coração

Abstract

The simulation of the heart electromechanical activity is a relevant tool for the interpretation and studies of physiological measures and various cardiac phenomena. However, computational models for this purpose may be computationally costly. Thus, three simplified models which were able to quantitatively reproduce the phenomenon of cardiac myocyte contraction were proposed in this work. At the cellular level, they were able to quantitatively reproduce the phenomenon of cardiac myocyte contraction. A parameter adjustment via genetic algorithm was performed to obtain these models. The proposed models with adjusted parameters presented satisfactory results for the reproduction of the active force of the heart with the advantage of being based on only two ordinary differential equations. In addition, the final model was validated using simulations involving extra-systoles, being able to reproduce the phenomenon of alternation in the active stress.