Avaliação da pressão arterial em pacientes com periodontite crônica e doença renal crônica (estágios 3, 4 e 5)

Abstract

Chronic kidney disease is considered a public health problem worldwide, mainly due to the high morbidity and mortality. The progressive and irreversible loss of kidney function provides various complications. Evaluation of risk factors is essential to reduce the risk of death in patients with chronic renal disease. Cardiovascular disease is the main cause of death from this disease followed by infection. The presence of oxide nitric(NO) in periodontal disease may reflect the participation of an additional mediator of bone resorption responsible for disease progression. In order to assess blood pressure included 34 patients allocated to four groups (9 with chronic kidney disease (CKD) and chronic periodontitis (CP), 9 CKD without PC, 11 PC with no systemic disease and 6 healthy controls). The CKD staging based on the KDOKI and glomerular filtration was estimated by equation CKD-EPI. The severity of CP was based on the classification of the American Academy of Periodontology. Nitrite levels were measured by Griess technique. Blood pressure was measured by ambulatory monitoring blood pressure (AMBP). Results showed individuals with CKD and PC had significantly higher serum nitrite when compared to controls. NO production is increased in CKD and PC, this will allows us to understand its role in the progression of these diseases. Blood pressure showed a tendency to show up high in the groups CKD and CKD / PC when compared to the control group. It is concluded that chronic periodontitis induces a systemic inflammatory response and patients with chronic kidney disease presented with greater severity.