Avaliação da atividade larvicida de tiossemicarbazonas frente ao Aedes aegypti

Abstract

Thiosemicarbazones are compounds obtained through the condensation of aldehydes or ketones and thiosemicarbazides that have great pharmacological potential. Despite being well reported the antimicrobial and cytotoxic potential of compounds containing this group, little attention has been addressed to their larvicidal potential. The present work evaluated the larvicidal activity of modified thiosemicarbazones in the aldehyde or ketone portion against larval and pupal stages from Aedes aegypti. The choice of larvae use of this vector was due to the social and financial impacts caused by the diseases transmitted by it. The methodologies applied in this study were those recommended by the World Health Organization in the “Guidelines for laboratory and field testing of mosquito larvicides”. During the activity evaluation on larvae at L4 stadium, it was possible to observe that of the five evaluated compounds, three showed activity in concentrations below than 50 ppm. In the adult emergence inhibition experiment, it was observed that an increase in the exposure time to thiosemicarbazones during adult-pupa-larvae metamorphosis led to the increase in the mortality. These data corroborate the larvicidal potential of thiosemicarbazone class compounds.