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dc.contributor.advisor1Ribeiro, Raquel Tognon-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/9001547181522263pt_BR
dc.contributor.referee1Bonomo, Larissa de Freitas-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/7165040970220720pt_BR
dc.contributor.referee2Silva, Pâmela Souza Almeida-
dc.contributor.referee2Lattesttp://lattes.cnpq.br/7072160577442095pt_BR
dc.creatorFaria, Gustavo Henrique Lima de Faria-
dc.creator.Latteshttp://lattes.cnpq.br/2202510662266893pt_BR
dc.date.accessioned2022-08-04T11:32:23Z-
dc.date.available2022-08-03-
dc.date.available2022-08-04T11:32:23Z-
dc.date.issued2022-07-29-
dc.identifier.urihttps://repositorio.ufjf.br/jspui/handle/ufjf/14305-
dc.description.abstractIntroduction: Complications of hemophilia, such as hemophilic arthropathies and the development of inhibitors against coagulation factor, have a great impact on the quality of life of the patients. The study of factors associated with these complications may contribute to their prevention. Objective: This study conducts a scoping review that seeks to identify and discuss genetic polymorphisms associated with complications of hemophilia A and hemophilia B. Methods: The methodology was conducted according to PRISMA Extension for Scoping Reviews (PRISMA-ScR) and PubMed was used as database to identify original articles published between 2011 and 2021, which associated genetic polymorphisms with complications of hemophilia. Results: 23 articles were selected, of which 22 of them identified polymorphisms associated with higher or lower risk of developing inhibitors in 24 genes and in one article identified polymorphisms associated with the higher risk of developing hemophilic arthropathy in 18 genes. In both cases, the genes involved were mostly associated with modulation of the immune and inflammatory response. Conclusion: Many polymorphisms in genes of coagulation factors and genes related to the immune and inflammatory response have been associated with the risk of developing inhibitors and hemophilic arthropathies and are possible molecular markers for treatment-related complications. However, there are few studies regarding the association of genetic polymorphisms and musculoskeletal complications.pt_BR
dc.description.resumo-pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Juiz de Fora - Campus Avançado de Governador Valadarespt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICV - Instituto de Ciências da Vidapt_BR
dc.publisher.initialsUFJF/GVpt_BR
dc.rightsAcesso Embargadopt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectHemophilia Apt_BR
dc.subjectHemophilia Bpt_BR
dc.subjectPolymorphism, geneticpt_BR
dc.subjectBlood coagulation factors inhibitorspt_BR
dc.subjectJoint Diseasespt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::FARMACIApt_BR
dc.titleGenetic markers associated with complications of hemophilia: A scoping reviewpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
Appears in Collections:Farmácia - Campus GV



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