Síntese de tiossemicarbazonas derivadas de chalconas

Abstract

Natural products are one of the main sources for the development of new drugs. However, factors as the increase in the chemical complexity of these biocompounds and/or the low yield in their extraction process has motivated its preparation via synthetic routes. In addition, the increasingly constant application of knowledge of medicinal chemistry is observed both in the search for pharmacophoric groups and in the use of chemical modification strategies that enhance the desired activity. Among natural products, chalcones are a class of compounds that have great potential as antimicrobials, cytotoxic and anti-inflammatory agents. Among the purely synthetic compounds, thiosemicarbazones also have a broad spectrum of pharmacological activities, including those mentioned above for chalcones. Considering that chalcones have a carbonyl group that can be chemically modified and that thiosemicarbazones are obtained from the reaction of thiosemicarbazides with carbonyl compounds, it was of interest of this work to prepare new thiosemicarbazones derived from chalcones that can present a potential synergism between the associated biological properties to these compounds. In this work the prepared chalcones and thiosemicarbazones derived from chalcones were characterized by vibrational spectroscopy in the infrared region and 1 H nuclear magnetic resonance. The data obtained suggest the formation of thirteen chalcones and nine thiosemicarbazones, three of the latter compounds being unpublished according to information in the literature.