Avaliação das informações técnicas contidas nas bulas de antibacterianos indicados para mastite bovina no Brasil em 2019

Abstract

Mastitis in an endemic disease that affects dairy herds worldwide, and can lead to major economic losses for the dairy industry. Brazil has its economy based on agribusiness, where the semi-intensive production system and tropical climante prevail, very favorable conditions for the development of mastitis. The basic principle of mastitis control is prevention, but even using preventive methods, new infections can occur. Antibacterial therapy is one of the procedures adopted to eliminate infeccions from the mammal gland. Medicines, such as antibacterials, play an important role in disease control and prevention. However, indiscriminate use has become worrisome due to the possibility of antimicrobial resistence and toxic effects on human health. In this context, it is essential that the package inserts of all mastitis antibacterials contain as much information as possible to ensure positive results after treatment, as well as providing improvements in the quality of milk offered na lower risk to consumers. Labels with incomplete or missing technical information lead to irracional use, contributing to possibility of antibacterial residue in milk and bacterial resistance. The objective of this study was to evaluate the technical information contained in the label of antibacterials indicated for the treatment of bovine mastitis available in the Brazilian market during 2019. The present work is a descriptive study in which labels of antibacterials indicated for bovine mastitis treatment served as a source of information. The technical information chosen as targets of this study were: antibacterial category, route of administration, insertion of the tube cannula for intramammary drug use, antibacterials categories, application period and withdrawal period. This technical information were chosen as a priority because they considerably influences the possibility of antibacterial resistance and the presence of residue in the milk. It was found that mosto f the labels do not meet or partially meet the requeriments of the Ministry of Agriculture, Lifestock and Supply (MAPA). It can be noticed delay or lack of actions in order to standardize the contetns of the leaflets according to the publication date of MAPA regulations. The faint aganist bacterial resistence has to involve all healthcare professionals, so veterinarians and pharmacists should come together and get more involved in these issues to assist the veterinary pharmaceutical industry in adjusting the package insert for the treatment and prevention of mastitis in Brazil.