Avaliação das condições periodontais e dos níveis séricos da interleucina-6 em indivíduos portadores de síndrome metabólica

Abstract

Many evidences indicate that there is a relationship between periodontitis and metabolic syndrome. At the same time, many authors affirm that the periodontal disease can contribute for the development of systemic alterations as obesity, diabetes and heart diseases. Through a cross-sectional case control study, we sought to assess the periodontal condition and serum levels of interleukin-6 in individuals with metabolic syndrome. We selected twenty patients with metabolic syndrome (case) and ten healthy patients with periodontal disease (control). All participants underwent a clinical periodontal examination and venous blood samples were obtained for research in the levels of interlekin-6, tryglicerides, HDL-C and glucose. We performed measurements of pressure and anthropometric indices. It was found that the periodontal conditions in healthy subjects were feelingly worse in the control group. There was 100% prevalence of periodontitis in the case group. Was observed in the group with metabolic syndrome, correlations between clinical attachment loss and fasting glucose, and also between IL-6 levels and HDL-C. In the control group no correlation between periodontal parameters and components of metabolic syndrome. However, IL-6 was positively related to clinical attachment loss. Results suggest that clinical attachment loss may have influence on glucose levels in patients with metabolic syndrome. Moreover, the high prevalence of periodontitis in these patients support the theory of a possible relationship between periodontal disease and metabolic syndrome.