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Fatal evolution of systemic Lupus erythematosus associated with Crohn's disease.pdf154.65 kBAdobe PDFVista previa
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Clase: Artigo de Periódico
Título : Fatal evolution of systemic Lupus erythematosus associated with Crohn's disease
Autor(es): Chebli, Júlio Maria Fonseca
Gaburri, Pedro Duarte
Souza, Aécio Flávio Meirelles de
Dias, Kátia Valéria Bastos
Cimino, Karla Oliveira
Carvalho-Filho, Roberto José de
Lucca, Fernando de Azevedo
Resumo: -
Resumen : The authors describe the case of a young Brazilian woman who was treated of ileocolonic Crohn's disease sparing rectum, as confirmed by colonoscopy and histopathological examination. After a 4-year course of sulfasalazine treatment, she presented with skin facial lesions in vespertilio, fever, arthralgias and high titers of anti-ANA and LE cells. A sulfasalazine-induced lupus syndrome was diagnosed, because after sulfasalazine withdrawal and a short course of prednisone, the clinical symptoms disappeared and the laboratory tests returned to normal. Mesalazine 3 g/day was started and the patient remained well for the next 3 years, when she was again admitted with fever, weakness, arthralgias, diplopy, strabismus and hypoaesthesia in both hands and feet, microhematuria, haematic casts, hypocomplementemia and high titers of autoimmune antibodies. A diagnosis of associated systemic lupus erythematosus was made. Although a pulsotherapy with methylprednisolone was started, no improvement was noticed. A cyclophosphamide trial was tried and again no positive results occurred. The patient evolved to severe clinical manifestations of general vasculitis affecting the central and peripheral nervous system and lungs, having a fatal evolution after 2 weeks. Although uncommon, the association of both disease may occur, and the authors call attention to this possibility, making a brief review of literature.
Palabras clave : Crohn disease
Lupus erythematosus
Systemic
CNPq: -
Idioma: eng
País: Brasil
Editorial : -
Sigla de la Instituición: -
Clase de Acesso: Acesso Aberto
DOI: http://dx.doi.org/10.1590/S0004-28032000000400007
URI : https://repositorio.ufjf.br/jspui/handle/ufjf/9175
Fecha de publicación : nov-2000
Aparece en las colecciones: Artigos de Periódicos



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