Tentativa de obtenção de sulfato de D-glicosamina a partir de mostos fermentados e síntese de complexos de ouro (I) com ligantes derivados de D-glicose

Abstract

Rheumatic diseases are nowadays one of the most recurring causes of physical disability among all sectors of society. The most common rheumatic diseases (in terms of incidence rates) are osteoarthritis (also known as arthrosis) and rheumatoid arthritis, which both affect world's population by millions and none of them have a known cure. Various types of chemical compounds, such as gold (I) and (III) salts and D-glucosamine, are widely studied by various research groups in the field of medicinal chemistry because of their potential application as treatment drugs for rheumatic diseases. In this work, a quitin-glucan complex was obtained from brewer's spent yeast, which was submitted to subsequent stages of acid and enzymatic hydrolysis. High quantities of D-glucose were harvested from these processes, but no measurable amount of D-glucosamine or any other saccharides were found. Also, four gold (I) complexes were produced by reacting Au[PEt3]Cl and Au[PPh3]Cl gold salts with D-gluconolactone-derived compounds. These were synthesized by working up D-gluconolactone through ketal and hidrazide formation followed by oxadiazolidine cyclization with CS2 to achieve the desired ligands. These ligands were subsequently treated with two different phosphine-containing gold salt moieties to obtain the corresponding gold (I) complexes. The aforementioned complexes and their corresponding ligands are being biologically tested for potential rheumatoid arthritis and ostheoarthrosis treatment, as well as leishmania treatment.