Associação entre defeitos do fechamento do tubo neural e disfunção do trato urinário inferior

Abstract

Introduction: The neural tube emerges in the third week of gestation, giving rise to the brain and spinal cord. Failures in its formation result in dysraphisms, resulting from incomplete fusion of the posterior vertebral arch and can be open, when there is protrusion of the neural tissue through the bone defect and closed or occult, when the neuronal alteration is covered by the skin.The isolated vertebral defect, known as spina bifida occulta or posterior arch closure defect is the most common form, in which there is no consensus as to the clinical significance. Methods: This is a retrospective, case control study, carried out by researching the medical records of patients seen at the UFJF Enuresis and UTID Outpatient Clinic between 2019 and 2023, with the aim of verifying the association of vertebral closure defect with enuresis manifestations and lower urinary tract dysfunction. A total of 143 patients were analyzed, with the exposure factor being the presence of the vertebral defect. The study group was made up of patients with the bone alteration and the control group of patients without the defect. The outcome variables evaluated were monosymptomatic and non-monosymptomatic enuresis, gender, and vesicointestinal dysfunction, using the Vancouver and DVSS scores. Results: We found no differences between the case and control groups in relation to the outcomes evaluated: monosymptomatic enuresis (p 0.279), non monosymptomatic enuresis (p0.279), lower urinary tract dysfunction analyzed using the Vancouver test (p0.976) and DVSS (p0.277),and gender(p0,362).Conclusion: There was no association between the posterior arch closure defect and the clinical manifestations of enuresis and lower urinary tract dysfunction in children and there was no association between the vertebral defect and gender.