Uma análise comparativa dos aspectos clínicos de todos os casos de adenocarcinoma polimorfo e adenocarcinoma cribriforme de glândulas salivares: uma revisão integrativa

Abstract

Polymorphic Adenocarcinoma (PA) is the second most common malignant tumor in Minor Salivary Glands (SMG), a variant of this lesion with more aggressive behavior has been described, Cribriform Adenocarcinoma of Salivary Glands (ACGS). The objective of this study is to compare the clinical aspects of all cases of AP and ACGS originating in GSM of the oral cavity through the analysis of observational studies described in the literature in the period between 2005 and 2023. To this end, an integrative review adapted to the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA) and some of the inclusion criteria were: studies in English and/or Portuguese, observational studies that contained clinical and histological data on each patient, articles that reported cases with primary lesion in the oral cavity originating from GSM. The databases used were: Pubmed, Lilacs (VHL), Scopus and Web of Science. Initially, 983 records were identified and after selection, 47 articles were chosen. As a result, it was found that: females were the most affected in both tumors, 61% in AP and 73.3% in ACGS; the average age variation in the two groups was 59.97 in the AP and 57.27 in the ACGS; most frequent anatomical location in AP was the palate (42.42%) and in ACGS the tongue (46.67%); lymph node metastasis was observed in 15.15% of AP cases and 60% of ACGS cases; the most commonly used treatment in AP was surgical excision (72.72%) and in ACGS it was surgical excision plus neck dissection (46.67%); relapses were seen in 9.09% of AP and 33.33% of ACGS; the average number of months of the follow-up period was 21.7 in the AP and 43.9 in the ACGS. It was concluded that, among the variables evaluated, the predilection for females and the average age of approximately 60 years are common to both tumors. Contrary to this, the clinical variables with quantitative differences were: anatomical location, lymph node metastasis, type of treatment and recurrence.