Efeitos do inibidor de aromatase na estrutura óssea e suas associações aos tecidos dentários

Abstract

The literature on the effects of aromatase inhibitors (AIs) on bone structure and their associations with dental tissues was reviewed. It could be concluded, based on the literature, that the reduction in bone mineral density was evidenced during the use of AIs, as indicated in the cellular activities in a hypoestrogenic state, however without proven to cause osteoporosis. In the oral cavity, adverse effects such as periodontal disease, menopausal gingivostomatitis and hyposalivation are commonly seen in patients using AI. In addition, the suppression of estradiol in in vitro studies demonstrated the presence of dentin remodeling, reduction of calcium (Ca) levels and lower compressive strength in the tooth structure. In this context, more research is needed to elucidate its use and its impacts on bone and dental tissues.