Existe associação entre Atopia e Câncer de Mama?

Abstract

This population-based case-control study was carried out with the aim of investigating the association between atopic diseases (asthma, atopic dermatitis and allergic rhinitis) and breast cancer. 145 patients with lesions suspicious of breast cancer were selected and divided into cases (cancer diagnosis n=72) and controls (benign diagnosis n=73) after definitive histopathological diagnosis by core biopsy and/or surgery. The patients underwent a clinical diagnosis of atopy (clinical assessment and questionnaire application), peripheral blood sampling and a prick test for the main house dust mites, and the results were analysed to assess the presence of an association between atopy and newly diagnosed breast cancer. The normality of the parametric data (IgE levels and eosinophil concentration) was checked with the Kolmogorov Smirnov normality test (α=0.05) and the data were presented as arithmetic mean ± standard deviation of the mean. For all analyses, the confidence interval was 95%, and the difference was significant when the p-value was <0.05. It was found that the mean value of the total IgE dosage in the cancer group was 130.8 kU/L (SD 265.1), while in the control group it was 61.8 kU/L (SD 85.6) with a p=0.05. With this investigation, it was concluded that there was a difference in total IgE values with higher levels in patients diagnosed with breast cancer compared to controls.